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Scientists at NDORMS have found that spermidine, a compound naturally found in foods like aged cheese and mushrooms, may help boost vaccine responses in older adults. It works by reducing signs of immune system aging, essentially helping the immune system act younger. This could mean better protection from flu shots and other vaccines for people over 60.
Evidence Assessment
Evidence Strength
Moderate
Study Type
Observational study with mechanistic data
Confidence
Medium
Key Findings
- Spermidine, a natural compound, was linked to fewer signs of immune system aging in older adults.
- Higher spermidine levels were associated with better vaccine responses, meaning the immune system reacted more strongly.
- The effect was seen with naturally occurring spermidine from diet, not high-dose supplements.
Practical Takeaways
- Add spermidine-rich foods to your diet: aged cheeses like parmesan, mushrooms, soybeans, and whole grains.
- Keep getting your vaccines as recommended — this is a potential booster, not a replacement for standard care.
Limitations & Caveats
- This was an observational study, so it can't prove cause and effect — it only shows a link between spermidine levels and immune health.
- The study looked at naturally occurring spermidine from diet, so we don't know if supplements would have the same effect or what the ideal dose would be.